How efficient is the pharmaceutical hot melt extruder in preparing poorly soluble drugs?

1. Improvement of product efficiency
The pharmaceutical hot melt extruder adopts a combined twin-screw design, which achieves molecular-level uniform mixing of drugs and carrier materials through high shear force and modular screw elements. For example: Preparation of amorphous solid dispersions: embedding poorly soluble drugs into water-soluble carriers to form amorphous dispersions and improve dissolution rates. This efficient dispersion is due to the high torque and precise temperature control of the twin screws, which prevents the drug from being inactivated by thermal degradation while ensuring the melting uniformity of the carrier material.

2. Continuous production
The pharmaceutical hot melt extruder supports seamless scale-up from the laboratory to the production line, shortening the R&D cycle. Traditional wet granulation requires multiple steps (mixing, granulation, drying), while the KTS pharmaceutical hot melt extruder can complete melting, mixing, and extrusion in one step. In addition, its solvent-free process avoids the risk of residual organic solvents, meets the requirements of green production, and is particularly suitable for the processing of heat-sensitive drugs (such as protein drugs).

3. Intelligent control and process stability
KTS integrates multi-zone independent temperature control system and online pressure monitoring (0-100 MPa) to ensure accurate and controllable process parameters. For different drug-carrier systems (such as PLGA, EC), a gradient temperature increase strategy can be set to avoid drug degradation caused by local overheating. The pharmaceutical hot melt extruder can record parameters such as screw speed and torque in real time to reduce errors caused by manual intervention.